Selected article for: "abnormal liver and acute respiratory syndrome"
Author: Cui, Hui-Juan; Tong, Xiao-Lin; Li, Ping; Hao, Ying-Xu; Chen, Xiao-Guang; Li, Ai-Guo; Zhang, Zhi-Yuan; Duan, Jun; Zhen, Min; Zhang, Bin; Hua, Chuan-Jin; Gong, Yue-Wen
Title: Serum hepatic enzyme manifestations in patients with severe acute respiratory syndrome: retrospective analysis.
  • Cord-id: tko8y5nm
  • Document date: 2004_1_1
    • ID: tko8y5nm
    Snippet: AIM To evaluate the hepatic function in patients with severe acute respiratory syndrome (SARS) and possible causes of hepatic disorder in these patients. METHODS One hundred and eighty-two patients with SARS were employed in a retrospective study that investigated hepatic dysfunction. Liver alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) were analyzed in these patients. Patients with different hospital treatments were further investigated. RESULTS
    Document: AIM To evaluate the hepatic function in patients with severe acute respiratory syndrome (SARS) and possible causes of hepatic disorder in these patients. METHODS One hundred and eighty-two patients with SARS were employed in a retrospective study that investigated hepatic dysfunction. Liver alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) were analyzed in these patients. Patients with different hospital treatments were further investigated. RESULTS Of the 182 patients, 128(70.3%) had abnormal ALT activity, 57(31.3%) had abnormal AST activity and 87(47.8%) had abnormal LDH activity. The peak of elevated hepatic enzyme activities occurred between the sixth day and the tenth day after the first day of reported fever. Of the 182 patients, 160(87.9%) had been treated with antibiotics, 137(75.2%) with Ribavirin, and 115(63.2%) with methylpredisolone. There was no statistically significant correlation between the duration of Ribavirin treatment and hepatic dysfunction. CONCLUSION Abnormal liver functions were common in patients with SARS and could be associated with virus replication in the liver.

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