Author: Chen, Mark I.C.; Lee, Vernon J.M.; Barr, Ian; Lin, Cui; Goh, Rachelle; Lee, Caroline; Singh, Baldev; Tan, Jessie; Lim, Wei-Yen; Cook, Alex R.; Ang, Brenda; Chow, Angela; Tan, Boon Huan; Loh, Jimmy; Shaw, Robert; Chia, Kee Seng; Lin, Raymond T.P.; Leo, Yee Sin
Title: Risk Factors for Pandemic (H1N1) 2009 Virus Seroconversion among Hospital Staff, Singapore Cord-id: dq2219ro Document date: 2010_10_25
ID: dq2219ro
Snippet: We describe incidence and risk factors for pandemic (H1N1) 2009 virus infection in healthcare personnel during the June–September 2009 epidemic in Singapore. Personnel contributed 3 serologic samples during June–October 2009, with seroconversion defined as a >4-fold increase in hemagglutination inhibition titers to pandemic (H1N1) 2009. Of 531 participants, 35 showed evidence of seroconversion. Seroconversion rates were highest in nurses (28/290) and lowest in allied health staff (2/116). Si
Document: We describe incidence and risk factors for pandemic (H1N1) 2009 virus infection in healthcare personnel during the June–September 2009 epidemic in Singapore. Personnel contributed 3 serologic samples during June–October 2009, with seroconversion defined as a >4-fold increase in hemagglutination inhibition titers to pandemic (H1N1) 2009. Of 531 participants, 35 showed evidence of seroconversion. Seroconversion rates were highest in nurses (28/290) and lowest in allied health staff (2/116). Significant risk factors on multivariate analysis were being a nurse (adjusted odds ratio [aOR] 4.5, 95% confidence interval [CI] 1.0–19.6) and working in pandemic (H1N1) 2009 isolation wards (aOR 4.5, 95% CI 1.3–15.6). Contact with pandemic (H1N1) 2009–infected colleagues (aOR 2.5, 95% CI 0.9–6.6) and larger household size (aOR 1.2, 95% CI 1.0–1.4) were of borderline significance. Our study suggests that seroconversion was associated with occupational and nonoccupational risk factors.
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