Author: Lin Li; Ting Sun; Yufei He; Wendong Li; Yubo Fan; Jing Zhang
Title: Epitope-based peptide vaccine design and target site characterization against novel coronavirus disease caused by SARS-CoV-2 Document date: 2020_2_27
ID: e9vq3fe3_32
Snippet: In this study, we characterized the physio-chemical characteristics of SARS-CoV-2 viral genome for epitope candidates and adopted an immune-informatics based pipeline with highly stringent criteria to identify S protein targeted B-and T-cell epitopes that may potentially promote an immune response in the host. The antigenicity, flexibility, solvent accessibility, disulphide bonds of predicted epitopes were evaluated, yielding four potential B-cel.....
Document: In this study, we characterized the physio-chemical characteristics of SARS-CoV-2 viral genome for epitope candidates and adopted an immune-informatics based pipeline with highly stringent criteria to identify S protein targeted B-and T-cell epitopes that may potentially promote an immune response in the host. The antigenicity, flexibility, solvent accessibility, disulphide bonds of predicted epitopes were evaluated, yielding four potential B-cell epitope and vaccine candidate. Allergenicity and toxicity analysis confirmed the four B-cell epitopes are of non-allergen and non-toxin. Stability analysis revealed that they can not be digested by multiple enzymes. In addition, two MHC class-I and nine MHC class-II binding Tcell epitopes were predicted to interact with numerous HLA alleles and to be highly antigenic in nature.
Search related documents:
Co phrase search for related documents- class ii and toxicity allergenicity analysis: 1, 2
- class ii and vaccine candidate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- class ii and viral genome: 1, 2, 3, 4, 5, 6, 7, 8, 9
- epitope candidate and toxicity allergenicity: 1, 2, 3
- epitope candidate and vaccine candidate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- HLA allele and toxicity allergenicity: 1
- HLA allele and vaccine candidate: 1, 2, 3, 4, 5
- HLA allele and viral genome: 1
- host immune response and toxicity allergenicity: 1
- host immune response and vaccine candidate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- host immune response and viral genome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- host immune response promote and vaccine candidate: 1
- host immune response promote and viral genome: 1
- immune informatics and toxicity allergenicity: 1, 2, 3
- immune informatics and toxicity allergenicity analysis: 1, 2
- immune informatics and vaccine candidate: 1, 2
- immune response and toxicity allergenicity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- immune response and vaccine candidate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- immune response and viral genome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
Co phrase search for related documents, hyperlinks ordered by date