Author: Lin Li; Ting Sun; Yufei He; Wendong Li; Yubo Fan; Jing Zhang
Title: Epitope-based peptide vaccine design and target site characterization against novel coronavirus disease caused by SARS-CoV-2 Document date: 2020_2_27
ID: e9vq3fe3_32
Snippet: In this study, we characterized the physio-chemical characteristics of SARS-CoV-2 viral genome for epitope candidates and adopted an immune-informatics based pipeline with highly stringent criteria to identify S protein targeted B-and T-cell epitopes that may potentially promote an immune response in the host. The antigenicity, flexibility, solvent accessibility, disulphide bonds of predicted epitopes were evaluated, yielding four potential B-cel.....
Document: In this study, we characterized the physio-chemical characteristics of SARS-CoV-2 viral genome for epitope candidates and adopted an immune-informatics based pipeline with highly stringent criteria to identify S protein targeted B-and T-cell epitopes that may potentially promote an immune response in the host. The antigenicity, flexibility, solvent accessibility, disulphide bonds of predicted epitopes were evaluated, yielding four potential B-cell epitope and vaccine candidate. Allergenicity and toxicity analysis confirmed the four B-cell epitopes are of non-allergen and non-toxin. Stability analysis revealed that they can not be digested by multiple enzymes. In addition, two MHC class-I and nine MHC class-II binding Tcell epitopes were predicted to interact with numerous HLA alleles and to be highly antigenic in nature.
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