Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study

Matthew J Cummings; Matthew R Baldwin; Darryl Abrams; Samuel D Jacobson; Benjamin J Meyer; Elizabeth M Balough; Justin G Aaron; Jan Claassen; LeRoy E Rabbani; Jonathan Hastie; Beth R Hochman; John Salazar-Schicchi; Natalie H Yip; Daniel Brodie; Max R O'Donnell

This study has many strengths. First, our study represents the largest cohort of patients with COVID-19-related critical illness reported to-date in the United States. Second, as patients were identified and data were collected prospectively, our findings reflect the ongoing outbreak of COVID-19 in New York City, currently the largest in the world. Third, we collected data using a globally harmonized, World Health Organization-endorsed case record form. Fourth, we augmented collection of standard clinical and laboratory data with clinically-and pathologicallyrelevant biomarkers, concentrations of which were available for nearly all patients. Lastly, given the prospective nature of our study, our analyses were performed with near-complete data, with in-hospital outcomes known for all included patients through April 14 th , 2020.