Author: Dominari, Asimina; Hathaway III, Donald; Pandav, Krunal; Matos, Wanessa; Biswas, Sharmi; Reddy, Gowry; Thevuthasan, Sindhu; Khan, Muhammad Adnan; Mathew, Anoopa; Makkar, Sarabjot Singh; Zaidi, Madiha; Fahem, Michael Maher Mourad; Beas, Renato; Castaneda, Valeria; Paul, Trissa; Halpern, John; Baralt, Diana
Title: Thymosin alpha 1: A comprehensive review of the literature Cord-id: 6jv42wok Document date: 2020_12_15
ID: 6jv42wok
Snippet: Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function. Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies, as an enhancer of vaccine response, and as a means of curbing morbidity and mortality in sepsis and numerous infections. Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by
Document: Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function. Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies, as an enhancer of vaccine response, and as a means of curbing morbidity and mortality in sepsis and numerous infections. Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells. In this review, we discuss key literature on the background knowledge and current clinical uses of thymosin alpha 1. Considering the known biochemical properties including antibacterial and antiviral properties, time-honored applications, and the new promising findings regarding the use of thymosin, we believe that thymosin alpha 1 deserves further investigation into its antiviral properties and possible repurposing as a treatment against severe acute respiratory syndrome coronavirus-2.
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