Author: M. Shaminur Rahman; M. Nazmul Hoque; M. Rafiul Islam; Salma Akter; A. S. M. Rubayet-Ul-Alam; Mohammad Anwar Siddique; Otun Saha; Md. Mizanur Rahaman; Munawar Sultana; M. Anwar Hossain
Title: Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2 etiologic agent of global pandemic COVID-19: an in silico approach Document date: 2020_3_31
ID: 0yqyclxk_3
Snippet: Linear epitopes prediction based on solvent-accessibility and flexibility revealed that 163 chain A of S protein possessed 15 epitopes, of which three epitopes having different residues 164 positions (395-514, 58-194, 1067-1146) were highly antigenic (score > 0.8). However, the B and 165 C chains had 18 and 19 epitopes, respectively, and of them three epitopes in chain B (residues 166 position 1067-1146, 89-194, 58-87) and two epitopes in chain C.....
Document: Linear epitopes prediction based on solvent-accessibility and flexibility revealed that 163 chain A of S protein possessed 15 epitopes, of which three epitopes having different residues 164 positions (395-514, 58-194, 1067-1146) were highly antigenic (score > 0.8). However, the B and 165 C chains had 18 and 19 epitopes, respectively, and of them three epitopes in chain B (residues 166 position 1067-1146, 89-194, 58-87) and two epitopes in chain C (residues position 56-194, 1067-167 1146) seem to be highly antigenic (score > 0.8) ( Table 1 ). The amino acid residues 395-514 and 168 56-194 of the detected epitopes belonged to RBD and NTD regions of the S protein, 169 respectively. These regions were considered as the potential epitope candidates in the IEDB 170 analysis resource Elipro analysis. However, the epitopes with amino-acids position of 1067-1146 171
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