Can Human Overcome Viral Hijack-? Comprehensive review on COVID-19 in the view of diagnosis and mitigation across countries

Nagendran, Maheswari; John, Juliana; Annamalai, Kavithakani; Gandhi Sethuraman, Muthu Iswarya; Balamurugan, Nirkayani; Rajendran, Harish Kumar; Deen Fakrudeen, Mohammed Askkar; Chandrasekar, Ragavan; Ranjan, Shivendu; Padmanaban, Velayudhaperumal Chellam

The novel COVID-19, a pandemic disease, is showing an alarming spread and severity throughout the world. Globally, the community transmission of this disease is affecting people in large clusters and so it is necessary to mitigate and control them in order to minimise the social and economic consequences. This review emphasize on the origin of the coronoviral epidemics, discussion on the structural and functional basis of SARS-CoV-2, epidemiology, pathognomonic symptoms, fatality, available rapid diagnostic methods and proposed possible treatment methods for the treatment of COVID-19. The diagnostic markers with respect to genetic material of the virus based on PCR, CRISPR & APTAMER and with respect to proteins based on Antigens were discussed which provides new arena for the development. In control of a pandemic situation the policy adoption and implementation by the governments plays a major role and the policy implementation in different countries are discussed which establishes the effectiveness of the policies framed by the governments. The effectiveness of ethnic traditional medicines of various countries such as India and China in Immunity enhancement, along with their utilisation is also discussed. This review provides an insights towards the COVID-19 which helps in continuous investigation on different dimensions which could help us to understand the mysteries behind the havoc created by this invisible creature.