Author: Kozlovskaya, Liubov I.; Golinets, Anastasia D.; Eletskaya, Anastasia A.; Orlov, Alexey A.; Palyulin, Vladimir A.; Kochetkov, Sergey N.; Alexandrova, Liudmila A.; Osolodkin, Dmitry I.
Title: Selective Inhibition of Enterovirus A Species Members’ Reproduction by Furano[2, 3â€d]pyrimidine Nucleosides Revealed by Antiviral Activity Profiling against (+)ssRNA Viruses Cord-id: vp5xjkt6 Document date: 2018_2_27
ID: vp5xjkt6
Snippet: The rational design of broadâ€spectrum antivirals requires data on antiviral activity of compounds against multiple viruses, which are often not available. We have developed a panel of (+)ssRNA viruses composed of Enterovirus and Flavivirus genera members allowing to study these activity spectra. Antiviral activity profiling of a set of nucleoside analogues revealed N (4)â€hydroxycytidine as an efficient inhibitor of replication of coxsackieviruses and other enteroviruses, but ineffective agai
Document: The rational design of broadâ€spectrum antivirals requires data on antiviral activity of compounds against multiple viruses, which are often not available. We have developed a panel of (+)ssRNA viruses composed of Enterovirus and Flavivirus genera members allowing to study these activity spectra. Antiviral activity profiling of a set of nucleoside analogues revealed N (4)â€hydroxycytidine as an efficient inhibitor of replication of coxsackieviruses and other enteroviruses, but ineffective against tickâ€borne encephalitis virus. Furano[2, 3â€d]pyrimidine nucleosides with nâ€pentyl or nâ€hexyl tails showed selective inhibition of Enterovirus A representatives. 5â€(Tetradecâ€1â€ynâ€1â€yl)â€uridine showed selective inhibition of tickâ€borne encephalitis virus at the micromolar level.
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