Green Economy Approach to Develop Bioactive Dexamethasone Analogue Scaffold Against SARS CoV-2

Singhal, Kavita; Kumar, Ajay

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemic has become an extraordinary medical challenging issue that caused severe negative impacts on population health and the world economy. The epidemic has completely engulfed the human civilization on a large scale. Therefore, the development of some promising, cheap, and eco-friendly drugs is required for the treatment of SARS-CoV-2. Recently, dexamethasone (DMs), a corticosteroid medication has a wide therapeutic application including against SARS-CoV-2. DMs has been found useful in controlling the damaging effect of cytokines as well as it’s over production in various critically ill patients with SARS-CoV-2 but some drawbacks of DMs were also reported in literatures. The complex chemical synthesis of DMs has generated abundant amounts of waste products that affect the yield of DMs along with its cost. Hence, to tackle the above explained issues of DMs, analogues of DMs have been required to synthesis by the green approach. So that it will be non-hazardous toward the body and easily available to mankind. Green synthesis of DMs analogue scaffold contains ionic liquid (IL) as both solvent and catalyst but a number of studies show that the extraction of IL from synthesis reaction is quite a difficult process. Hence, a supportive catalyst is required for easy extraction of IL from reaction mixture. Magnetic bio-char (MBC) and magnetic nano particles (MNP) are considered as promising candidates for the supportive catalyst with IL as they can easily extract from synthesis reaction via magnetic separation method. The sol-gel method provides an effective means to develop the eco-friendly biocatalysts MBC-IL and MNP-IL. Moreover, MBC-IL and MNP-IL are efficient to load numerous drugs and using in drug delivery system. Therefore, the present investigation provides an effective means to develop a cost-effective, non-hazardous biocompatible, and reusable catalyst with green principle approach for the synthesis of DMs as they are useful for the treatment of SARS-CoV-2 and similar types of disease.