Selected article for: "dna duplex and nucleoside triphosphate"
Author: Yang, Nan; Tanner, Julian A.; Zheng, Bo‐Jian; Watt, Rory M.; He, Ming‐Liang; Lu, Lin‐Yu; Jiang, Jie‐Qing; Shum, Ka‐To; Lin, Yong‐Ping; Wong, Kin‐Ling; Lin, Marie C. M.; Kung, Hsiang‐Fu; Sun, Hongzhe; Huang, Jian‐Dong
Title: Bismuth Complexes Inhibit the SARS Coronavirus
  • Cord-id: o4lncsc7
  • Document date: 2007_7_23
    • ID: o4lncsc7
    Snippet: Hold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth‐based drugs should be further evaluated for the treatment of SCV infections in vivo. ss=single‐stranded DNA, ds=duplex DNA.[Image: see text]
    Document: Hold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth‐based drugs should be further evaluated for the treatment of SCV infections in vivo. ss=single‐stranded DNA, ds=duplex DNA.[Image: see text]

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