Author: Sahajpal, Nikhil Shri; Mondal, Ashis K.; Njau, Allan; Ananth, Sudha; Jones, Kimya; Ahluwalia, Pankaj K.; Ahluwalia, Meenakshi; Jilani, Yasmeen; Chaubey, Alka; Hegde, Madhuri; Kota, Vamsi; Rojiani, Amyn; Kolhe, Ravindra
Title: Proposal of Reverse Transcription-PCR–Based Mass Population Screening for SARS-CoV-2 (COVID-19) Cord-id: uphdzj5l Document date: 2020_7_30
ID: uphdzj5l
Snippet: Testing for SARS-CoV-2 has lagged behind in many countries due to lack of adequate test kits and bottlenecks in the analytical process. The aim of this study was to investigate the feasibility and accuracy of a sample pooling approach for wide-scale population screening for COVID-19. A total of 940 nasopharyngeal-swab samples (934 negative and 6 positive) previously tested for SARS-CoV-2 were de-identified and assigned random numbers for analysis. From this, 94 pools of 10 samples each were crea
Document: Testing for SARS-CoV-2 has lagged behind in many countries due to lack of adequate test kits and bottlenecks in the analytical process. The aim of this study was to investigate the feasibility and accuracy of a sample pooling approach for wide-scale population screening for COVID-19. A total of 940 nasopharyngeal-swab samples (934 negative and 6 positive) previously tested for SARS-CoV-2 were de-identified and assigned random numbers for analysis. From this, 94 pools of 10 samples each were created. Automated RNA extraction followed by RT-PCR was carried out in a 96 well plate. Positive pools were identified and the individual samples were re-analyzed.
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