Estimating excess 1- year mortality from COVID-19 according to underlying conditions and age in England: a rapid analysis using NHS health records in 3.8 million adults

Amitava Banerjee; Laura Pasea; Steve Harris; Arturo Gonzalez-Izquierdo; Ana Torralbo; Laura Shallcross; Mahdad Noursadeghi; Deenan Pillay; Christina Pagel; Wai Keong Wong; Claudia Langenberg; Bryan Williams; Spiros Denaxas; Harry Hemingway

The risk factors and diseases were defined using Read clinical terminology systems in primary care diagnosis and the 10th version of the International Statistical Classification of Diseases (ICD-10) for hospital admissions as per previously validated CALIBER phenotypes (13, 14, (17) (18) (19) . Hypertension was defined based on recorded values in primary care according to the most recent guidelines: ≥140 mmHg systolic blood pressure (or ≥150 mmHg for people aged ≥60 years without diabetes and chronic kidney disease) and/or ≥90 mmHg diastolic blood pressure (17) . Diabetes was defined at baseline (including type 1, type 2, or uncertain type) on the basis of coded diagnoses recorded in CPRD or HES at or before study entry (18) . Severe obesity was defined as body mass index >=40kg/m 2 . CVD was defined as the 12 most common symptomatic manifestations: chronic stable angina, unstable angina, myocardial infarction, unheralded death from coronary heart disease, heart failure, cardiac arrest/sudden coronary death, transient ischaemic attack, ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, peripheral arterial disease, and abdominal aortic aneurysm, as . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.