Author: Ren, Heather M.; Lukacher, Aron E.
Title: IL-21 in Homeostasis of Resident Memory and Exhausted CD8 T Cells during Persistent Infection Cord-id: gd4640yk Document date: 2020_9_22
ID: gd4640yk
Snippet: CD4 T cells guide the development of CD8 T cells into memory by elaborating mitogenic and differentiation factors and by licensing professional antigen-presenting cells. CD4 T cells also act to stave off CD8 T cell dysfunction during repetitive antigen stimulation in persistent infection and cancer by mitigating generation of exhausted T cells (T(EX)). CD4 T cell help is also required for establishing and maintaining tissue-resident memory T cells (T(RM)), the nonrecirculating memory T cell subs
Document: CD4 T cells guide the development of CD8 T cells into memory by elaborating mitogenic and differentiation factors and by licensing professional antigen-presenting cells. CD4 T cells also act to stave off CD8 T cell dysfunction during repetitive antigen stimulation in persistent infection and cancer by mitigating generation of exhausted T cells (T(EX)). CD4 T cell help is also required for establishing and maintaining tissue-resident memory T cells (T(RM)), the nonrecirculating memory T cell subset parked in nonlymphoid tissues to provide frontline defense against reinvading pathogens. Interleukin (IL)-21 is the signature cytokine secreted by follicular helper CD4 T cells (T(FH)) to drive B cell expansion and differentiation in germinal centers to mount high-affinity, isotype class-switched antibodies. In several infection models, IL-21 has been identified as the CD4 T help needed for formation and survival of T(RM) and T(EX). In this review, we will explore the different memory subsets of CD8 T cells in persistent infections, the metabolic profiles associated with each, and evidence documenting the importance of CD4 T cell-derived IL-21 in regulating CD8 T(RM) and T(EX) development, homeostasis, and function.
Search related documents:
Co phrase search for related documents- active area and local systemic: 1, 2
- active area and lymph node: 1
- active infection and acute infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- active infection and local systemic: 1
- active infection and lung carcinoma: 1
- active infection and lymph node: 1, 2, 3, 4
- active infection inflammation and acute infection: 1
- active infection inflammation and lung carcinoma: 1
- acute infection and adoptive transfer: 1, 2, 3, 4, 5, 6
- acute infection and local systemic: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- acute infection and long term persist: 1
- acute infection and lung carcinoma: 1
- acute infection and lymph node: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- adoptive transfer and local systemic: 1
- adoptive transfer and lymph node: 1, 2, 3, 4
- local systemic and lymph node: 1, 2, 3, 4, 5, 6, 7
Co phrase search for related documents, hyperlinks ordered by date