On the progress of 3D-printed hydrogels for tissue engineering

Advincula, Rigoberto C.; Dizon, John Ryan C.; Caldona, Eugene B.; Viers, Robert Andrew; Siacor, Francis Dave C.; Maalihan, Reymark D.; Espera, Alejandro H.

ABSTRACT: Additive manufacturing or more commonly known as 3D printing, is currently driving innovations and applications in diverse fields such as prototyping, manufacturing, aerospace, education, and medicine. Recent technological and materials research breakthroughs have enabled 3D bioprinting, where biomaterials and cells are used to create scaffolds and functional living tissues (e.g. skin, cartilage, etc.). This prospective focuses on the classification and applications of hydrogels, and design considerations in their production (i.e. physical and biological parameters). The materials for 3D printing of hydrogels, such as biopolymers, synthetic polymers, and nanocomposites, are mainly discussed. More importantly, future perspectives on 3D printing hydrogels including new materials, 4D printing, emerging printing technologies, etc. and their importance in biomedical and bioengineering applications are discussed. GRAPHIC ABSTRACT: [Image: see text]