Author: Malla, Tika R.; Tumber, Anthony; John, Tobias; Brewitz, Lennart; Strain-Damerell, Claire; Owen, C David; Lukacik, Petra; Chan, H. T. Henry; Maheswaran, Pratheesh; Salah, Eidarus; Duarte, Fernanda; Yang, Haitao; Rao, Zihe; Walsh, Martin A.; Schofield, Christopher J.
Title: Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 M(pro) inhibitors Cord-id: w4dht8s7 Document date: 2021_2_11
ID: w4dht8s7
Snippet: The main viral protease (M(pro)) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry M(pro) assay. The results reveal some β-lactams, including penicillin esters, are active site reacting M(pro) inhibitors, thus highlighting the potential of acylating agents for M(pro) inhibition.
Document: The main viral protease (M(pro)) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry M(pro) assay. The results reveal some β-lactams, including penicillin esters, are active site reacting M(pro) inhibitors, thus highlighting the potential of acylating agents for M(pro) inhibition.
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