A Multiscale and Comparative Model for Receptor Binding of 2019 Novel Coronavirus and the Implication of its Life Cycle in Host Cells

Zhaoqian Su; Yinghao Wu

In order to further explore the impacts of our rigid-body simulation results on the cells. On the other side, in order to avoid viral spread, our innate immune system triggers 29 inflammatory signaling pathways in the infected cells [30] . For instance, the viral RNAs The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.20.958272 doi: bioRxiv preprint receptors initiates the signaling cascade by interacting with the mitochondrial antiviral-1 signaling (MAVS) protein [32] . The aggregation of MAVS on the surface of 2 mitochondria will trigger the NF-κB signaling pathway that turns on gene expression of 3 specific cytokines [S] to stimulate the inflammatory responses [33, 34] . The inflammation 4 of host organism leads to the apoptosis of infected cells and the removal of virus by 5 recruited immune cells such as microphages. In summary, the change of concentration for 6 each variable in above system can be described by following set of ordinary differential 7 equations (ODE).