Author: Demonbreun, Alexis R; Sancilio, Amelia; Velez, Matt E; Ryan, Daniel T; Pesce, Lorenzo; Saber, Rana; Vaught, Lauren A; Reiser, Nina L; Hsieh, Ryan R; D'Aquila, Richard T; Mustanski, Brian; McDade, Thomas W; McNally, Elizabeth M
Title: COVID-19 mRNA Vaccination Generates Greater Immunoglobulin G Levels in Women Compared to Men Cord-id: h0yi3ub9 Document date: 2021_1_1
ID: h0yi3ub9
Snippet: We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0 µg/mL, 51.6% vs 3.3 µg/mL, 36.4%). After 2 doses, IgG levels remained significantly higher for women (30.4 µg/mL) compared to
Document: We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0 µg/mL, 51.6% vs 3.3 µg/mL, 36.4%). After 2 doses, IgG levels remained significantly higher for women (30.4 µg/mL) compared to men (20.6 µg/mL), while percent inhibition was similar (98.4% vs 97.7%). Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.
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