Selected article for: "cell virus infect and virus infection"
Author: Zanza, Christian; Tassi, Michele Fidel; Romenskaya, Tatsiana; Piccolella, Fabio; Abenavoli, Ludovico; Franceschi, Francesco; Piccioni, Andrea; Ojetti, Veronica; Saviano, Angela; Canonico, Barbara; Montanari, Mariele; Zamai, Loris; Artico, Marco; Robba, Chiara; Racca, Fabrizio; Longhitano, Yaroslava
Title: Lock, Stock and Barrel: Role of Renin-Angiotensin-Aldosterone System in Coronavirus Disease 2019
  • Cord-id: gwysk8il
  • Document date: 2021_7_11
    • ID: gwysk8il
    Snippet: Since the end of 2019, the medical-scientific community has been facing a terrible pandemic caused by a new airborne viral agent known as SARS-CoV2. Already in the early stages of the pandemic, following the discovery that the virus uses the ACE2 cell receptor as a molecular target to infect the cells of our body, it was hypothesized that the renin-angiotensin-aldosterone system was involved in the pathogenesis of the disease. Since then, numerous studies have been published on the subject, but
    Document: Since the end of 2019, the medical-scientific community has been facing a terrible pandemic caused by a new airborne viral agent known as SARS-CoV2. Already in the early stages of the pandemic, following the discovery that the virus uses the ACE2 cell receptor as a molecular target to infect the cells of our body, it was hypothesized that the renin-angiotensin-aldosterone system was involved in the pathogenesis of the disease. Since then, numerous studies have been published on the subject, but the exact role of the renin-angiotensin-aldosterone system in the pathogenesis of COVID-19 is still a matter of debate. RAAS represents an important protagonist in the pathogenesis of COVID-19, providing the virus with the receptor of entry into host cells and determining its organotropism. Furthermore, following infection, the virus is able to cause an increase in plasma ACE2 activity, compromising the normal function of the RAAS. This dysfunction could contribute to the establishment of the thrombo-inflammatory state characteristic of severe forms of COVID-19. Drugs targeting RAAS represent promising therapeutic options for COVID-19 sufferers.

    Search related documents:
    Co phrase search for related documents
    • abdominal pain and activity level: 1
    • abdominal pain and acute ards respiratory distress syndrome: 1, 2, 3, 4
    • abdominal pain and acute kidney injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26
    • abdominal pain and acute myocardial injury: 1
    • abdominal pain and adipose tissue: 1, 2, 3
    • abdominal pain and adrenal cortex: 1
    • abdominal pain and liver damage: 1, 2, 3, 4, 5, 6, 7, 8
    • abdominal pain and liver dysfunction: 1, 2, 3, 4
    • abdominal pain and liver function: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
    • abdominal pain and liver function test: 1
    • abdominal pain and liver produce: 1
    • abdominal pain and liver tissue: 1
    • abdominal pain and local systemic: 1, 2, 3, 4
    • abdominal pain and low blood pressure: 1
    • abdominal pain and low respiratory tract: 1
    • abdominal pain and lung damage: 1
    • abdominal pain and lung function: 1, 2, 3, 4
    • abdominal pain and lung injury: 1, 2, 3, 4, 5
    • abdominal pain vomiting and ace enzyme: 1, 2, 3