Author: Liu, Zhelong; Bai, Xi; Han, Xia; Jiang, Wangyan; Qiu, Lin; Chen, Shi; Yu, Xuefeng
Title: The association of diabetes and the prognosis of COVID-19 patients: a retrospective study Cord-id: 7b6btzrx Document date: 2020_8_25
ID: 7b6btzrx
Snippet: Abstract Aims This study evaluated the impact of previous glycemic control and in-hospital use of antidiabetic/antihypertensive drugs on the prognosis of COVID-19 patients with diabetes. Methods In this retrospective cohort study, consecutive inpatients with laboratory confirmed COVID-19 were enrolled from Tongji Hospital (Wuhan, China). Patients without diabetes were matched to those with diabetes based on age, sex, and comorbidities. All patients were followed up to a clinical endpoint (discha
Document: Abstract Aims This study evaluated the impact of previous glycemic control and in-hospital use of antidiabetic/antihypertensive drugs on the prognosis of COVID-19 patients with diabetes. Methods In this retrospective cohort study, consecutive inpatients with laboratory confirmed COVID-19 were enrolled from Tongji Hospital (Wuhan, China). Patients without diabetes were matched to those with diabetes based on age, sex, and comorbidities. All patients were followed up to a clinical endpoint (discharge, worsening including transferring to ICU or immediate death). Data and outcomes were extracted from medical records and analyzed. Results 64 patients with pre-existing diabetes were included in this study, with 128 matched patients without diabetes included as a control group. Patients with diabetes had a higher rate of worsening (18.8% versus 7.8%, p=0.025). Multivariable regression showed increased odds of worsening associated with previous glycemic control reflected by HbA1c (odds ratio 3.29, 95% CI 1.19-9.13, p=0.022) and receiver-operating characteristics (ROC) curve identified HbA1c of 8.6% (70 mmol/mol) as the optimal cut-off value. Univariate analysis demonstrated the in-hospital use of antidiabetic/antihypertensive drugs were not associated with a higher risk of worsening. Conclusions COVID-19 patients with diabetes had a higher risk of worsening, especially those with poorly-controlled HbA1c, with an optimal cut-off value of 8.6%. The in-hospital use of antidiabetic/antihypertensive drugs were not associated with increased odds of worsening in patients with diabetes.
Search related documents:
Co phrase search for related documents- a1c hba1c glycated hemoglobin and logistic regression analysis: 1
- aceis arbs and admission day: 1
- aceis arbs and admission prior: 1, 2, 3, 4, 5
- aceis arbs and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- aceis arbs and logistic regression analysis: 1, 2, 3
- aceis arbs and logistic regression model: 1, 2
- admission day and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- admission day and logistic regression analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- admission day and logistic regression model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- admission prior and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29
- admission prior and logistic regression analysis: 1, 2, 3, 4, 5, 6, 7, 8
- admission prior and logistic regression model: 1, 2, 3, 4, 5
- admission report and logistic regression: 1, 2, 3
- logistic regression analysis and lymphopenia neutrophil: 1, 2, 3
- logistic regression and lymphopenia neutrophil: 1, 2, 3, 4, 5
- logistic regression model and lymphopenia neutrophil: 1
Co phrase search for related documents, hyperlinks ordered by date