Author: Belsher, Jon L.; Gay, Peter; Brinton, Margo; DellaValla, Joseph; Ridenour, Robert; Lanciotti, Robert; Perelygin, Andrey; Zaki, Sherif; Paddock, Christopher; Querec, Troy; Zhu, Tuofu; Pulendran, Bali; Eidex, Rachel B.; Hayes, Edward
Title: Fatal multiorgan failure due to yellow fever vaccine-associated viscerotropic disease Cord-id: he7au9nf Document date: 2007_12_5
ID: he7au9nf
Snippet: Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) is a rare complication of yellow fever (YF) vaccination. A previously healthy 22-year-old female died following YF vaccination despite aggressive measures. Serial viral load titers, cytokine levels and host genetic factors were evaluated in an attempt to understand this unusual and lethal outcome. The patient's high-titer vaccine viremia and possibly related minor genetic anomalies provide clues to exploring the etiology of YEL-AVD.
Document: Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) is a rare complication of yellow fever (YF) vaccination. A previously healthy 22-year-old female died following YF vaccination despite aggressive measures. Serial viral load titers, cytokine levels and host genetic factors were evaluated in an attempt to understand this unusual and lethal outcome. The patient's high-titer vaccine viremia and possibly related minor genetic anomalies provide clues to exploring the etiology of YEL-AVD.
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