Author: Ting Ding; Jinjin Zhang; Tian Wang; Pengfei Cui; Zhe Chen; Jingjing Jiang; Su Zhou; Jun Dai; Bo Wang; Suzhen Yuan; Wenqing Ma; Lingwei Ma; Yueguang Rong; Jiang Chang; Xiaoping Miao; Xiangyi Ma; Shixuan Wang
Title: A Multi-hospital Study in Wuhan, China:Protective Effects of Non-menopause and Female Hormones on SARS-CoV-2 infection Document date: 2020_3_30
ID: lplodn60_4
Snippet: Interestingly, it is expressed more in male lungs than female lungs 3 . Consistently, the expression of ACE2 is downregulated by estrogen E2 4 . This was confirmed in animal experiments, showing that estrogen mitigates the susceptibility and the severity of phenotype for SARS-CoV, while ovariectomy or intervention with estrogen receptor inhibitors increased the mortality of female mice 5 . An anti-virus drug study showed that estrogen receptor in.....
Document: Interestingly, it is expressed more in male lungs than female lungs 3 . Consistently, the expression of ACE2 is downregulated by estrogen E2 4 . This was confirmed in animal experiments, showing that estrogen mitigates the susceptibility and the severity of phenotype for SARS-CoV, while ovariectomy or intervention with estrogen receptor inhibitors increased the mortality of female mice 5 . An anti-virus drug study showed that estrogen receptor inhibitors possess a great potency in antiviral activity screening against MERS-CoV, SARS-CoV and other RNA virus, and they also have an anti-Ebola virus effect in mice 6 . These studies suggest that E2 might play a protective role in SARS-CoV or MERS-CoV infection with lower susceptibility, severity and better outcomes of their corresponding diseases. However, the effect of sex hormones and All rights reserved. No reuse allowed without permission.
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