Author: Ting Ding; Jinjin Zhang; Tian Wang; Pengfei Cui; Zhe Chen; Jingjing Jiang; Su Zhou; Jun Dai; Bo Wang; Suzhen Yuan; Wenqing Ma; Lingwei Ma; Yueguang Rong; Jiang Chang; Xiaoping Miao; Xiangyi Ma; Shixuan Wang
Title: A Multi-hospital Study in Wuhan, China:Protective Effects of Non-menopause and Female Hormones on SARS-CoV-2 infection Document date: 2020_3_30
ID: lplodn60_50
Snippet: This study has several limitations. First, correlation analysis showed that E2 is negatively correlated with COVID-19's severity, but the causal relationship between them remains unclear. Second, the serum E2 level was just from once blood sample regardless of phase of menstrual cycle, so that the results may not completely reflect the average E2 level and its effects. In order to alleviate this error, we divided menstrual cycle into follicular a.....
Document: This study has several limitations. First, correlation analysis showed that E2 is negatively correlated with COVID-19's severity, but the causal relationship between them remains unclear. Second, the serum E2 level was just from once blood sample regardless of phase of menstrual cycle, so that the results may not completely reflect the average E2 level and its effects. In order to alleviate this error, we divided menstrual cycle into follicular and luteal phase when analyzed with E2. Third, the sample size of serum sex hormones, 78, might not be large enough. More samples are needed to further determine the relationship of E2 level with the outcomes. All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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