Author: Caporale, Nicolò; Testa, Giuseppe
Title: COVID-19 lessons from the dish: Dissecting CNS manifestations through brain organoids. Cord-id: wna5zo0d Document date: 2020_11_11
ID: wna5zo0d
Snippet: SARS-CoV-2 is increasingly understood as a systemic disease with pathogenic manifestations beyond the respiratory tract. Recent work by Ramani et al (2020) dissects the cellular and molecular mechanisms of COVID-19's neurotrophic properties, using viral exposure of human brain organoids. Their findings highlight neurons as primary target of cerebral SARS-CoV-2 infection and uncover its Tau-related neurotoxicity.
Document: SARS-CoV-2 is increasingly understood as a systemic disease with pathogenic manifestations beyond the respiratory tract. Recent work by Ramani et al (2020) dissects the cellular and molecular mechanisms of COVID-19's neurotrophic properties, using viral exposure of human brain organoids. Their findings highlight neurons as primary target of cerebral SARS-CoV-2 infection and uncover its Tau-related neurotoxicity.
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