Author: Reusken, C; Mou, H; Godeke, G J; van der Hoek, L; Meyer, B; Müller, M A; Haagmans, B; de Sousa, R; Schuurman, N; Dittmer, U; Rottier, P; Osterhaus, A; Drosten, C; Bosch, B J; Koopmans, M
Title: Specific serology for emerging human coronaviruses by protein microarray. Cord-id: 79bzd4nl Document date: 2013_1_1
ID: 79bzd4nl
Snippet: We present a serological assay for the specific detection of IgM and IgG antibodies against the emerging human coronavirus hCoV-EMC and the SARS-CoV based on protein microarray technology. The assay uses the S1 receptor-binding subunit of the spike protein of hCoV-EMC and SARS-CoV as antigens. The assay has been validated extensively using putative cross-reacting sera of patient cohorts exposed to the four common hCoVs and sera from convalescent patients infected with hCoV-EMC or SARS-CoV.
Document: We present a serological assay for the specific detection of IgM and IgG antibodies against the emerging human coronavirus hCoV-EMC and the SARS-CoV based on protein microarray technology. The assay uses the S1 receptor-binding subunit of the spike protein of hCoV-EMC and SARS-CoV as antigens. The assay has been validated extensively using putative cross-reacting sera of patient cohorts exposed to the four common hCoVs and sera from convalescent patients infected with hCoV-EMC or SARS-CoV.
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