Obstructive sleep apnea (OSA) and outcomes from coronavirus disease 2019 (COVID-19) pneumonia: A Systematic Review and Meta-Analysis

Hariyanto, Timotius Ivan; Kurniawan, Andree

BACKGROUND: Obstructive sleep apnea (OSA) is the most prevalent sleep-related breathing disorder which could impair someone's quality of life and is also associated with poor outcomes from many diseases. Currently, the evidence regarding the link between OSA and coronavirus disease 2019 (COVID-19) is still conflicting. This study aims to analyze the relationship between OSA and poor outcomes of COVID-19. MATERIALS AND METHODS: We systematically searched the PubMed and Europe PMC database using specific keywords related to our aims until December 10(th), 2020. All articles published on COVID-19 and OSA were retrieved. The quality of the study was assessed using the Newcastle Ottawa Scale (NOS) tool for observational studies. Statistical analysis was done using Review Manager 5.4 software. RESULTS: A total of 21 studies with 54,276 COVID-19 patients were included in this meta-analysis. This meta-analysis showed that OSA was associated with composite poor outcome [OR 1.72 (95% CI 1.55 – 1.91), p < 0.00001, I(2) = 36%, random-effect modelling] and its subgroup which comprised of severe COVID-19 [OR 1.70 (95% CI 1.18 – 2.45), p = 0.005], ICU admissions [OR 1.76 (95% CI 1.51 – 2.05), p < 0.00001], the need for mechanical ventilation [OR 1.67 (95% CI 1.48 – 1.88), p < 0.00001], and mortality [OR 1.74 (95% CI 1.39 – 2.19), p < 0.00001]. CONCLUSIONS: Extra care and close monitoring should be provided to patients with OSA to minimize the risk of infections. Simple questionnaires such as STOP-Bang questionnaire can be used for screening patients who may be at risk for severe adverse outcomes.