Author: Ting Ding; Jinjin Zhang; Tian Wang; Pengfei Cui; Zhe Chen; Jingjing Jiang; Su Zhou; Jun Dai; Bo Wang; Suzhen Yuan; Wenqing Ma; Lingwei Ma; Yueguang Rong; Jiang Chang; Xiaoping Miao; Xiangyi Ma; Shixuan Wang
Title: A Multi-hospital Study in Wuhan, China:Protective Effects of Non-menopause and Female Hormones on SARS-CoV-2 infection Document date: 2020_3_30
ID: lplodn60_47
Snippet: Previous studies have suggested that high doses of E2 may inhibit the production of inflammatory cytokines (e.g., IL-1β, TNF-α), whereas stimulation with E2 at its physiological level enhances their production 18, 19 . After viral infection, proinflammatory cytokines/chemokines secreted by macrophages induced various antiviral mechanisms. Several clinical studies reported that levels of proinflammatory cytokines/chemokines, including IL-6, IL-8.....
Document: Previous studies have suggested that high doses of E2 may inhibit the production of inflammatory cytokines (e.g., IL-1β, TNF-α), whereas stimulation with E2 at its physiological level enhances their production 18, 19 . After viral infection, proinflammatory cytokines/chemokines secreted by macrophages induced various antiviral mechanisms. Several clinical studies reported that levels of proinflammatory cytokines/chemokines, including IL-6, IL-8, IFN-γ, MCP-1, and IP-10, are highly increased in patients with SARS, some of which were correlated with ARDS, respiratory syncytial virus infections and human infection by avian influenza viruses 20, 21 . In our study, the levels of IL6 and IL8 were negatively related to both disease severity and composite end points, and IL2R and IL10 were related to composite end All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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