Author: Brunelli, Alessandro; Chaudhuri, Nilanjan; Kefaloyannis, Manos; Milton, Richard; Pompili, Cecilia; Tcherveniakov, Peter; Papagiannopoulos, Kostas
Title: Eurolung risk score is associated with long-term survival following curative resection for lung cancer Cord-id: y4ome6bc Document date: 2020_8_24
ID: y4ome6bc
Snippet: ABSTRACT Objective To verify whether the Eurolung score was associated with long term prognosis after lung cancer resection. Methods 1359 consecutive patients undergoing anatomic lung resection (1136 lobectomies, 103 pneumonectomies, 120 segmentectomies) (2014-2018) were analysed. The parsimonious aggregate Eurolung2 score was calculated for each patient. Median follow up was 802 days. Survival distribution was estimated by the Kaplan-Meier method. Cox proportional hazard regression and competin
Document: ABSTRACT Objective To verify whether the Eurolung score was associated with long term prognosis after lung cancer resection. Methods 1359 consecutive patients undergoing anatomic lung resection (1136 lobectomies, 103 pneumonectomies, 120 segmentectomies) (2014-2018) were analysed. The parsimonious aggregate Eurolung2 score was calculated for each patient. Median follow up was 802 days. Survival distribution was estimated by the Kaplan-Meier method. Cox proportional hazard regression and competing risk regression analyses were used to assess the independent association of Eurolung with overall and disease specific survival. Results Patients were grouped into 4 classes according to their Eurolung scores (A 0-2.5, B 3-5, C 5.5-6.5, D 7-11.5). Most patients were in class A (52%) and B (33%), 8% were in class C and 7% in class D. Five-year overall survival decreased across the categories (A: 75%; B: 52%; C: 29%; D: 27%, log rank p<0.0001). The score stratified well the 3-year overall survival in patients with either pT1 (p<0.0001) or pT>1 (p<0.0001). In addition, the different classes were associated with incremental risk of long-term overall mortality in patients with pN0 (p<0.0001) and with positive nodes (p=0.0005). Cox proportional hazard regression and competing regression analyses showed that Eurolung aggregate score remained significantly associated with overall (HR 1.19,p<0.0001) and disease specific survival after adjusting for pT and pN stage (HR 1.09,p=0.005). Conclusions Eurolung aggregate score was associated with long-term survival after curative resection for cancer. This information may be valuable to inform the shared decision-making process and the multidisciplinary team discussion assisting in the selection of the most appropriate curative treatment in high-risk patients.
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