Author: Williams, Thomas L.; Colzani, Maria T.; Macrae, Robyn G. C.; Robinson, Emma L.; Bloor, Stuart; Greenwood, Edward J. D.; Zhan, Jun Ru; Strachan, Gregory; Kuc, Rhoda E.; Nyimanu, Duuamene; Maguire, Janet J.; Lehner, Paul J.; Sinha, Sanjay; Davenport, Anthony P.
Title: Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection Cord-id: gu8fdppu Document date: 2021_7_29
ID: gu8fdppu
Snippet: Patients with cardiovascular comorbidities are more susceptible to severe infection with SARS-CoV-2, known to directly cause pathological damage to cardiovascular tissue. We outline a screening platform using human embryonic stem cell-derived cardiomyocytes, confirmed to express the protein machinery critical for SARS-CoV-2 infection, and a SARS-CoV-2 spike-pseudotyped virus system. The method has allowed us to identify benztropine and DX600 as novel inhibitors of SARS-CoV-2 infection in a clini
Document: Patients with cardiovascular comorbidities are more susceptible to severe infection with SARS-CoV-2, known to directly cause pathological damage to cardiovascular tissue. We outline a screening platform using human embryonic stem cell-derived cardiomyocytes, confirmed to express the protein machinery critical for SARS-CoV-2 infection, and a SARS-CoV-2 spike-pseudotyped virus system. The method has allowed us to identify benztropine and DX600 as novel inhibitors of SARS-CoV-2 infection in a clinically relevant stem cell-derived cardiomyocyte line. Discovery of new medicines will be critical for protecting the heart in patients with SARS-CoV-2, and for individuals where vaccination is contraindicated.
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