Selected article for: "acute phase and previous study"
Author: Pingping Zhang; Qi Gao; Tang Wang; Yuehua Ke; Fei Mo; Ruizhong Jia; Wanbing Liu; Lei Liu; Shangen Zheng; Yuzhen Liu; Luping Li; Yao Wang; Lei Xu; Kun Hao; Ruifu Yang; Shiyue Li; Changqing Lin; Yong Zhao
Title: Evaluation of recombinant nucleocapsid and spike proteins for serological diagnosis of novel coronavirus disease 2019 (COVID-19)
  • Document date: 2020_3_20
    • ID: 7atoko6c_28
    Snippet: The IgM-specific sensitivities for ELISA (from 1:100 to 1:800) are all higher than 1 those for IgG (1:20-1:80), mostly because the positive serial samples came from 2 patients during the acute phase of COVID-19 infection. Additionally, the antigenicity 3 of full-length rN was higher than that of fragments rN1 and rN2, which is consistent 4 with the findings from our previous study on SARS-CoV [8]. However, the higher 5 sensitivity of rN1 over rN2.....
    Document: The IgM-specific sensitivities for ELISA (from 1:100 to 1:800) are all higher than 1 those for IgG (1:20-1:80), mostly because the positive serial samples came from 2 patients during the acute phase of COVID-19 infection. Additionally, the antigenicity 3 of full-length rN was higher than that of fragments rN1 and rN2, which is consistent 4 with the findings from our previous study on SARS-CoV [8]. However, the higher 5 sensitivity of rN1 over rN2 suggests that the antigenicity of the protein fragment at 6 the NH 2 terminus of the N protein was higher than that at the COOH terminus, which 7 is the opposite result of our previous study on SARS-CoV author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

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