Predictive value of D‐dimer/albumin ratio and fibrinogen/albumin ratio for in‐hospital mortality in patients with COVID‐19

Küçükceran, Kadir; Ayranci, Mustafa Kürşat; Girişgin, Abdullah Sadık; Koçak, Sedat

INTRODUCTION: Due to the high mortality of coronavirus disease 2019 (COVID‐19), there are difficulties in the managing emergency department. We investigated whether the D‐dimer/albumin ratio (DAR) and fibrinogen/albumin ratio (FAR) predict mortality in the COVID‐19 patients. METHODS: A total of 717 COVID‐19 patients who were brought to the emergency department from March to October 2020 were included in the study. Levels of D‐dimer, fibrinogen and albumin, as well as DAR, FAR, age, gender and in‐hospital mortality status of the patients, were recorded. The patients were grouped by in‐hospital mortality. Statistical comparison was conducted between the groups. RESULTS: Of the patients included in the study, 371 (51.7%) were male, and their median age was 64 years (50‐74). There was in‐hospital mortality in 126 (17.6%) patients. The area under the curve (AUC) and odds ratio values obtained by DAR to predict in‐hospital mortality were higher than the values obtained by the all other parameters (AUC of DAR, albumin, D‐dimer, FAR and fibrinogen: 0.773, 0.766, 0.757, 0.703 and 0.637, respectively; odds ratio of DAR > 56.36, albumin < 4.015, D‐dimer > 292.5, FAR > 112.33 and fibrinogen > 423:7.898, 6.216, 6.058, 4.437 and 2.794, respectively). In addition; patients with concurrent DAR > 56.36 and FAR > 112.33 had an odds ratio of 21.879 with respect to patients with concurrent DAR < 56.36 and FAR < 112.33. CONCLUSION: DAR may be used as a new marker to predict mortality in COVID‐19 patients. In addition, the concurrent high DARs and FARs were found to be more valuable in predicting in‐hospital mortality than either separately.