Immunotoxic role of Organophosphates: an unseen risk escalating SARS-CoV-2 pathogenicity

Rajak, Prem; Ganguly, Abhratanu; Sarkar, Saurabh; Mandi, Moutushi; Dutta, Moumita; Podder, Sayanti; Khatun, Salma; Roy, Sumedha

Consistent gathering of immunotoxic-substances on earth is a serious global-issue affecting people under pathogenic-stress. Organophosphates are among such hazardous-compounds that are ubiquitous in nature. They fuel oxidative-stress to impair antiviral immune-response in living-entities. Aside, organophosphate ignites cytokine-burst and pyroptosis in broncho-alveolar chambers leading to severe respiratory-ailments. At present, we witness COVID-19 outbreak caused by SARS-CoV-2. Infection triggers cytokine-storm coupled with inflammatory-manifestations and pulmonary-disorders in patients. Since organophosphate-exposure promotes necroinflammation and respiratory-troubles hence during current pandemic-situation, additional exposure to such chemicals can exacerbate inflammatory-outcome and pulmonary-maladies in patients, or pre-exposure to organophosphates might turn-out to be a risk-factor for compromised-immunity. Fortunately, antioxidants alleviate organophosphate-induced immunosuppression and hence under co-exposure circumstances, dietary-intake of antioxidants would be beneficial to boost immunity against SARS-CoV-2 infection.