Author: Wickström, Malin; Larsson, Rolf; Nygren, Peter; Gullbo, Joachim
Title: Aminopeptidase N (CD13) as a target for cancer chemotherapy Cord-id: hct5nz05 Document date: 2011_1_30
ID: hct5nz05
Snippet: The enzyme aminopeptidase N (APN, also known as CD13) is a Zn(2+) dependent membraneâ€bound ectopeptidase that degrades preferentially proteins and peptides with a Nâ€terminal neutral amino acid. Aminopeptidase N has been associated with the growth of different human cancers and suggested as a suitable target for antiâ€cancerous therapy. Different approaches have been used to develop new drugs directed to this target, including enzyme inhibitors as well as APNâ€targeted carrier constructs. T
Document: The enzyme aminopeptidase N (APN, also known as CD13) is a Zn(2+) dependent membraneâ€bound ectopeptidase that degrades preferentially proteins and peptides with a Nâ€terminal neutral amino acid. Aminopeptidase N has been associated with the growth of different human cancers and suggested as a suitable target for antiâ€cancerous therapy. Different approaches have been used to develop new drugs directed to this target, including enzyme inhibitors as well as APNâ€targeted carrier constructs. This review discusses the prevalence and possible function of APN in malignant diseases, mainly solid tumors, as well as its “drugability†evaluated in preclinical in vivo models, and also provides a brief overview of current clinical trials focused on APN. (Cancer Sci 2011; 102: 501–508)
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