Author: Nasa Sinnott-Armstrong; Daniel Klein; Brendan Hickey
Title: Evaluation of Group Testing for SARS-CoV-2 RNA Document date: 2020_3_30
ID: bgm3bt78_29
Snippet: Further extensions of this approach might be justifiable given the current extreme limitations on testing resources. For instance, testing efficiency can be increased at the expense of specificity by pooling people in close contact (ex. family groups, work units) into a single sample prior to group allocation or RNA extraction. This reduces test volume by a constant factor under the assumption that individuals in close contact have positively cor.....
Document: Further extensions of this approach might be justifiable given the current extreme limitations on testing resources. For instance, testing efficiency can be increased at the expense of specificity by pooling people in close contact (ex. family groups, work units) into a single sample prior to group allocation or RNA extraction. This reduces test volume by a constant factor under the assumption that individuals in close contact have positively correlated infection status and that cluster identification is more vital to suppression than determining a particular individual's infection status. In addition, pooling samples from the same individual (sputum, nasopharyngeal swab, etc) will obtain similar benefits with essentially no loss of information.
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