Author: Granata, Guido; Bartoloni, Alessandro; Codeluppi, Mauro; Contadini, Ilaria; Cristini, Francesco; Fantoni, Massimo; Ferraresi, Alice; Fornabaio, Chiara; Grasselli, Sara; Lagi, Filippo; Masucci, Luca; Puoti, Massimo; Raimondi, Alessandro; Taddei, Eleonora; Trapani, Filippo Fabio; Viale, Pierluigi; Johnson, Stuart; Petrosillo, Nicola
Title: The Burden of Clostridioides Difficile Infection during the COVID-19 Pandemic: A Retrospective Case-Control Study in Italian Hospitals (CloVid) Cord-id: 5z974nea Document date: 2020_11_27
ID: 5z974nea
Snippet: Data on the burden of Clostridioides difficile infection (CDI) in Coronavirus Disease 2019 (COVID-19) patients are scant. We conducted an observational, retrospective, multicenter, 1:3 case (COVID-19 patients with CDI)-control (COVID-19 patients without CDI) study in Italy to assess incidence and outcomes, and to identify risk factors for CDI in COVID-19 patients. From February through July 2020, 8402 COVID-19 patients were admitted to eight Italian hospitals; 38 CDI cases were identified, inclu
Document: Data on the burden of Clostridioides difficile infection (CDI) in Coronavirus Disease 2019 (COVID-19) patients are scant. We conducted an observational, retrospective, multicenter, 1:3 case (COVID-19 patients with CDI)-control (COVID-19 patients without CDI) study in Italy to assess incidence and outcomes, and to identify risk factors for CDI in COVID-19 patients. From February through July 2020, 8402 COVID-19 patients were admitted to eight Italian hospitals; 38 CDI cases were identified, including 32 hospital-onset-CDI (HO-CDI) and 6 community-onset, healthcare-associated-CDI (CO-HCA-CDI). HO-CDI incidence was 4.4 × 10,000 patient-days. The percentage of cases recovering without complications at discharge (i.e., pressure ulcers, chronic heart decompensation) was lower than among controls (p = 0.01); in-hospital stays was longer among cases, 35.0 versus 19.4 days (p = 0.0007). The presence of a previous hospitalisation (p = 0.001), previous steroid administration (p = 0.008) and the administration of antibiotics during the stay (p = 0.004) were risk factors associated with CDI. In conclusions, CDI complicates COVID-19, mainly in patients with co-morbidities and previous healthcare exposures. Its association with antibiotic usage and hospital acquired bacterial infections should lead to strengthen antimicrobial stewardship programmes and infection prevention and control activities.
Search related documents:
Co phrase search for related documents- abdominal infection and logistic regression: 1, 2
- abdominal infection and logistic regression analysis: 1
- abnormal blood and acute care: 1
- abnormal blood and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- abnormal blood and logistic regression analysis: 1, 2, 3, 4, 5, 6, 7
- acute care and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- acute care and logistic regression analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37
- acute cholecystitis and logistic regression: 1, 2, 3, 4, 5
- acute cholecystitis and logistic regression analysis: 1, 2
- log likelihood and logistic regression: 1, 2
- log likelihood and logistic regression analysis: 1
Co phrase search for related documents, hyperlinks ordered by date