A Multi-hospital Study in Wuhan, China:Protective Effects of Non-menopause and Female Hormones on SARS-CoV-2 infection

Ting Ding; Jinjin Zhang; Tian Wang; Pengfei Cui; Zhe Chen; Jingjing Jiang; Su Zhou; Jun Dai; Bo Wang; Suzhen Yuan; Wenqing Ma; Lingwei Ma; Yueguang Rong; Jiang Chang; Xiaoping Miao; Xiangyi Ma; Shixuan Wang

Continuous variables were expressed as the means and standard deviations or medians and interquartile ranges (IQR) as appropriate. Categorical variables were summarized as the counts and percentages in each category. Mann-Whitney U test were applied to continuous variables, chi-square tests and Fisher's exact tests were used for categorical variables as appropriate. Multivariate Cox proportional hazards models were used to evaluate the independent effect of menstruation regularity on prolonging hospitalization time, controlling age, severity and comorbidity. Multiple logistic regression model was used to assess the independent adjusted relationship between menstruation regularity and disease severity controlling age and E2 level. Pearson's correlation analysis was used to explore the relationship between E2 and cytokines related to immunity and inflammation. All analyses were conducted with SPSS All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.