Author: Nasa Sinnott-Armstrong; Daniel Klein; Brendan Hickey
Title: Evaluation of Group Testing for SARS-CoV-2 RNA Document date: 2020_3_30
ID: bgm3bt78_7
Snippet: First, we evaluated whether group testing might improve upon existing individual-test methodologies. Testing three pooling strategies -four-well pooling (pooling four adjacent wells in a single dimension), 96-well (8x12) plate column and row pooling, and 384-well (16x24) plate column and row pooling -we found that all improve significantly upon naive testing, and that each performed better for a particular prevalence, as expected ( Figure 2 ). Al.....
Document: First, we evaluated whether group testing might improve upon existing individual-test methodologies. Testing three pooling strategies -four-well pooling (pooling four adjacent wells in a single dimension), 96-well (8x12) plate column and row pooling, and 384-well (16x24) plate column and row pooling -we found that all improve significantly upon naive testing, and that each performed better for a particular prevalence, as expected ( Figure 2 ). All three required fewer tests than the naive method at prevalence less than 10%. We have implemented these simulations in an R package that is available at https:// gitlab.com/technopolymath/pooled-diagnostics, and an interactive web visualization is available at https://technopolymath.shinyapps.io/pooled_covid_testing/.
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