Author: Jiao-Mei Huang; Syed Sajid Jan; Xiaobin Wei; Yi Wan; Songying Ouyang
Title: Evidence of the Recombinant Origin and Ongoing Mutations in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Document date: 2020_3_17
ID: fw4pmaoc_6
Snippet: To explore the emergence of SARS-CoV-2 in humans, we investigated CoVs S-protein and its RBD as they are responsible for determining the host range ( Table 1) . The S-protein amino acid sequence identity between SARS-CoV-2 and related beta-CoVs showed that bat/Yunnan/RaTG13 shares highest similarity of 97.43%. However, the amino acid sequence identity of RBD of SARS-CoV-2 with bat/Yunnan/RaTG13 is 89.57%. On the other hand, Beta-CoVs from pangoli.....
Document: To explore the emergence of SARS-CoV-2 in humans, we investigated CoVs S-protein and its RBD as they are responsible for determining the host range ( Table 1) . The S-protein amino acid sequence identity between SARS-CoV-2 and related beta-CoVs showed that bat/Yunnan/RaTG13 shares highest similarity of 97.43%. However, the amino acid sequence identity of RBD of SARS-CoV-2 with bat/Yunnan/RaTG13 is 89.57%. On the other hand, Beta-CoVs from pangolin sources (pangolin/Guandong/1/2019 and . CC-BY 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.16.993816 doi: bioRxiv preprint pangolin/Guangdong/lung08) revealed highest RBD amino acid sequence identity of 96.68% and 96.08% respectively with SARS-CoV-2. These indication shows the existence of homologous recombination events within the S-protein gene between bat and pangolin CoVs.
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