Author: Emily R Adams; Rekha Anand; Monique I Andersson; Kathryn Auckland; J Kenneth Baillie; Eleanor Barnes; John Bell; Tamsin Berry; Sagida Bibi; Miles Carroll; Senthil Chinnakannan; Elizabeth Clutterbuck; Richard J Cornall; Derrick W Crook; Thushan De Silva; Wanwisa Dejnirattisai; Kate E Dingle; Christina Dold; David W Eyre; Helen Farmer; Sarah J Hoosdally; Alistair Hunter; Katie Jeffrey; Paul Klenerman; Julian Knight; Clarice Knowles; Andrew J Kwok; Ullrich Leuschner; Chang Liu; Cesar Lopez-Camacho; Philippa C Matthews; Hannah McGivern; Alexander J Mentzer; Jonathan Milton; Juthathip Mongkolsapaya; Shona C Moore; Marta S Oliveira; Fiona Pereira; Timothy Peto; Rutger J Ploeg; Andrew Pollard; Tessa Prince; David J Roberts; Justine K Rudkin; Gavin R Screaton; Malcolm G Semple; Donal T Skelly; Elliot Nathan Smith; Julie Staves; David Stuart; Piyada Supasa; Tomas Surik; Pat Tsang; Lance Turtle; A Sarah Walker; Beibei Wang; Charlotte Washington; Nicholas Watkins; James Whitehouse; Sally Beer; Robert Levin; Alexis Espinosa; Dominique Georgiou; Jose Carlos Martinez Garrido; Hannah Thraves; Elena Perez Lopez; Maria del Rocio Fernandez Mendoza; Alberto Jose Sobrino Diaz; Veronica Sanchez
Title: Evaluation of antibody testing for SARS-Cov-2 using ELISA and lateral flow immunoassays Document date: 2020_4_20
ID: 5trox1i5_23
Snippet: We also considered performance relative to ELISA (Table S5 , Figure S1 ), because the LFIA devices target the same antibodies. We considered patients positive by this alternative standard if their IgG OD reading exceeded the threshold above (since no samples were IgMpositive, IgG-negative). Sensitivity of antibody detection by LFIA ranged from 65% (95%CI 46-80%) to 85% (66-96%) and specificity from 93% (95%CI 83-98%) to 100% (94-100%); however, t.....
Document: We also considered performance relative to ELISA (Table S5 , Figure S1 ), because the LFIA devices target the same antibodies. We considered patients positive by this alternative standard if their IgG OD reading exceeded the threshold above (since no samples were IgMpositive, IgG-negative). Sensitivity of antibody detection by LFIA ranged from 65% (95%CI 46-80%) to 85% (66-96%) and specificity from 93% (95%CI 83-98%) to 100% (94-100%); however, the device with the highest sensitivity had one of the lowest specificities ( Figure S1 ). There was no evidence of differences in sensitivity (p≥0.010, cf. p=0.0014 threshold) or specificity between devices (p≥0. 19 ).
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