Author: Dachuan Lin; Lei Liu; Mingxia Zhang; Yunlong Hu; Qianting Yang; Jiubiao Guo; Youchao Dai; Yuzhong Xu; Yi Cai; Xinchun Chen; Kaisong Huang; Zheng Zhang
Title: Evaluations of serological test in the diagnosis of 2019 novel coronavirus (SARS-CoV-2) infections during the COVID-19 outbreak Document date: 2020_3_30
ID: 6hep2lin_1
Snippet: Serums from 29 healthy individuals, 51 tuberculosis patients, and 79 SARS-CoV-2 confirmed patients 25 were employed to evaluate the performance of this approach. Compared to the IgM testing, the IgG 26 testing was more reliable in which it identified 65 SARS-CoV-2 infections from the 79 confirmed 27 patients and only two false-positive cases from the 80 control group with a sensitivity and specificity 28 reaching 82.28% and 97.5%, respectively. H.....
Document: Serums from 29 healthy individuals, 51 tuberculosis patients, and 79 SARS-CoV-2 confirmed patients 25 were employed to evaluate the performance of this approach. Compared to the IgM testing, the IgG 26 testing was more reliable in which it identified 65 SARS-CoV-2 infections from the 79 confirmed 27 patients and only two false-positive cases from the 80 control group with a sensitivity and specificity 28 reaching 82.28% and 97.5%, respectively. However, only a slight difference (not statistically 29 significant) in the detected cases of SARS-CoV-2 infections was observed between the IgM and IgG 30 testing manner in patients at a different time of onset of disease. A performance comparison 31 between an ELISA kit using the same nucleocapsid antigen and our chemiluminescence method was 32 undertaken. The same false-positive cases were seen in both methods from the paired control group, 33 while ELISA kit can only detect half of the SARS-CoV-2 infections from paired SARS-CoV-2 confirmed 34 patients group than that of the chemiluminescence method, indicating a higher performance for the 35 chemiluminescence-immunoassay approach. Together, our studies provide a useful and valuable Introduction 39 Coronavirus, belonging to the family of Coronavirdiae and order of Nidovirales, is a group of 40 enveloped, non-segmented positive-sense RNA virus that has been reported to be able to infect 41 humans and a wide range of animals including cattle, swine, chicken, cat, horse, camels, rodent, bats 42 and snakes and so forth (1) (2) (3) . Based on the genetic properties, coronavirus was further divided into 43 . CC-BY-NC 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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