Author: Megan C. Cohan; Ammon E. Posey; Steven J. Grigsby; Anuradha Mittal; Alex S. Holehouse; Paul J. Buske; Petra A. Levin; Rohit V. Pappu
Title: Evolved sequence features within the intrinsically disordered tail influence FtsZ assembly and bacterial cell division Document date: 2018_4_14
ID: 2rzfuy33_31
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/301622 doi: bioRxiv preprint span a range from 0.18 -0.4. However, Z-ring formation is compromised for cells expressing variants CTLV5 (κ=0.46) and CTLV6 (κ=0.72) ( Figure 3B ). These results suggest that increased segregation of oppositely charged residues within the CTT sequence leads to a disruption of Z-ring formation and hap.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/301622 doi: bioRxiv preprint span a range from 0.18 -0.4. However, Z-ring formation is compromised for cells expressing variants CTLV5 (κ=0.46) and CTLV6 (κ=0.72) ( Figure 3B ). These results suggest that increased segregation of oppositely charged residues within the CTT sequence leads to a disruption of Z-ring formation and haphazard localization of FtsZ puncta that in turn inhibit cell division.
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