Author: Megan C. Cohan; Ammon E. Posey; Steven J. Grigsby; Anuradha Mittal; Alex S. Holehouse; Paul J. Buske; Petra A. Levin; Rohit V. Pappu
Title: Evolved sequence features within the intrinsically disordered tail influence FtsZ assembly and bacterial cell division Document date: 2018_4_14
ID: 2rzfuy33_5
Snippet: Calorimetric measurements suggest that the formation of FtsZ assemblies requires the crossing of a critical concentration threshold (Caplan and Erickson, 2003; Chen et al., 2005) . This apparent cooperativity is at odds with the observation that FtsZ forms stable singlestranded filaments, which is the defining characteristic of isodesmic assembly (Oosawa and Kasai, 1962) . Numerous models have been developed to describe how FtsZ assembles coopera.....
Document: Calorimetric measurements suggest that the formation of FtsZ assemblies requires the crossing of a critical concentration threshold (Caplan and Erickson, 2003; Chen et al., 2005) . This apparent cooperativity is at odds with the observation that FtsZ forms stable singlestranded filaments, which is the defining characteristic of isodesmic assembly (Oosawa and Kasai, 1962) . Numerous models have been developed to describe how FtsZ assembles cooperatively. These models suggest that FtsZ subunits might undergo conformational changes to facilitate the population of a high affinity state that favors polymerization (Miraldi et al., 2008) .
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