Author: Ria Lassaunière; Anders Frische; Zitta B Harboe; Alex CY Nielsen; Anders Fomsgaard; Karen A Krogfelt; Charlotte S Jørgensen
Title: Evaluation of nine commercial SARS-CoV-2 immunoassays Document date: 2020_4_10
ID: 8cg5yj20_13
Snippet: The distance of data points from the manufacturer recommended cut-off values and confidence in assigning a positive or negative status differed between the three assays ( Figure 1A ). The distribution of positive and negative data points were distinct for the Wantai Total Ab assay, with a cut-off value above all the control sera samples, which allowed for unequivocal interpretation. Conversely, the Euroimmun IgA and IgG assays data had a less dis.....
Document: The distance of data points from the manufacturer recommended cut-off values and confidence in assigning a positive or negative status differed between the three assays ( Figure 1A ). The distribution of positive and negative data points were distinct for the Wantai Total Ab assay, with a cut-off value above all the control sera samples, which allowed for unequivocal interpretation. Conversely, the Euroimmun IgA and IgG assays data had a less distinct separation, resulting in a 'grey zone' of borderline data points to which a positive or negative status could not be assigned. Both case and control sera had borderline or inconclusive data points.
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