Selected article for: "ancestral lineage and recombinant region"
Author: Maciej F Boni; Philippe Lemey; Xiaowei Jiang; Tommy Tsan-Yuk Lam; Blair Perry; Todd Castoe; Andrew Rambaut; David L Robertson
Title: Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic
  • Document date: 2020_3_31
    • ID: h2uc7ria_16
    Snippet: Using the most conservative approach to identifying a non-recombinant genomic region (NRR1), SARS-CoV-2 forms a sister lineage with RaTG13, with genetically related cousin lineages of coronavirus sampled in pangolins in Guangdong and Guangxi provinces ( Figure 2 ). Given that these pangolin viruses are ancestral to the progenitor of the RaTG13/SARS-CoV-2 lineage, it is more likely that they are also picking up viruses from bats. While pangolins c.....
    Document: Using the most conservative approach to identifying a non-recombinant genomic region (NRR1), SARS-CoV-2 forms a sister lineage with RaTG13, with genetically related cousin lineages of coronavirus sampled in pangolins in Guangdong and Guangxi provinces ( Figure 2 ). Given that these pangolin viruses are ancestral to the progenitor of the RaTG13/SARS-CoV-2 lineage, it is more likely that they are also picking up viruses from bats. While pangolins could be acting as intermediate hosts for bat viruses to get into humansthey develop severe respiratory disease (Lie et al., 2019) and commonly come into contact with people as they are trafficked in large numbers for consumption and use in Chinese medicine -pangolin infection is not a requirement for bat viruses to cross into humans.

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