Author: Shitao Rao; Alexandria Lau; Hon-Cheong So
Title: Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of 2019-nCov: A Mendelian Randomization analysis Document date: 2020_3_8
ID: myh73pe6_51
Snippet: On the other hand, we also wish to highlight some results could be false negatives. The main reason for false negatives is the limited sample size of GTEx, and that for some exposure traits, the number of instruments available may be small. For example, in our analysis, we do not find evidence of hypertension or blood pressure, history of coronary heart disease and stroke to be casually linked to ACE2 expression, although patients with severe inf.....
Document: On the other hand, we also wish to highlight some results could be false negatives. The main reason for false negatives is the limited sample size of GTEx, and that for some exposure traits, the number of instruments available may be small. For example, in our analysis, we do not find evidence of hypertension or blood pressure, history of coronary heart disease and stroke to be casually linked to ACE2 expression, although patients with severe infections have been reported to be enriched for these comorbidities.
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