Author: Shukla, Nidhi; Prasad, Anchita; Kanga, Uma; Suravajhala, Renuka; Nigam, Vinod Kumar; Kishor, Pb Kavi; Polavarapu, Rathnagiri; Chaubey, Gyaneshwer; Singh, Keshav K; Suravajhala, Prashanth
Title: SARS-CoV-2 Transgressing LncRNAs Uncovers the Known Unknowns Cord-id: fk5mk6be Document date: 2021_1_1
ID: fk5mk6be
Snippet: SARS-CoV-2 harbors many known unknown regions in the form of hypothetical open reading frames (ORFs). While the mechanisms underlying the disease pathogenesis are not clearly understood, molecules such as long noncoding RNAs (lncRNAs) play a key regulatory role in the viral pathogenesis from endocytosis. We asked whether or not the lncRNAs in the host are associated with the viral proteins and argue that lncRNA-mRNA molecules related to viral infection may regulate SARS-CoV-2 pathogenesis. Towar
Document: SARS-CoV-2 harbors many known unknown regions in the form of hypothetical open reading frames (ORFs). While the mechanisms underlying the disease pathogenesis are not clearly understood, molecules such as long noncoding RNAs (lncRNAs) play a key regulatory role in the viral pathogenesis from endocytosis. We asked whether or not the lncRNAs in the host are associated with the viral proteins and argue that lncRNA-mRNA molecules related to viral infection may regulate SARS-CoV-2 pathogenesis. Towards the end of the perspective, we provide challenges and insights into investigating these transgression pathways.
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