Author: Matthew C. Wong; Sara J. Javornik Cregeen; Nadim J. Ajami; Joseph F. Petrosino
Title: Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019 Document date: 2020_2_13
ID: dnxhtbxn_10
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.07.939207 doi: bioRxiv preprint algorithms 8, 9 and sequence homology plots were calculated using RDP4 beta 99 10 . Distances of the selected coronavirus genomes relative to nCov-2019 were calculated using a 300bp window sliding every 10bp across the entire genome length. Sequence homology plots were visualized using R version 3.6.2 11 an.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.07.939207 doi: bioRxiv preprint algorithms 8, 9 and sequence homology plots were calculated using RDP4 beta 99 10 . Distances of the selected coronavirus genomes relative to nCov-2019 were calculated using a 300bp window sliding every 10bp across the entire genome length. Sequence homology plots were visualized using R version 3.6.2 11 and the ggplot2 visualization package 12 . The RBM segments as well as the Pro-Arg-Arg-Ala (PRRA) amino acid insertion region were excised from the full genome and pairwise aligned on NCBI using blastn and blastx. Multiple alignments of the both these regions were done using MAFFT v7.313 13 and visualized with MEGAX v10.1.7 14 .
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