Author: Jiao-Mei Huang; Syed Sajid Jan; Xiaobin Wei; Yi Wan; Songying Ouyang
Title: Evidence of the Recombinant Origin and Ongoing Mutations in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Document date: 2020_3_17
ID: fw4pmaoc_11
Snippet: With the global spread of SARS-CoV-2, its amino acid sequence is also significantly varied (Figure 3) . Usually, RNA viruses have high rate of genetic mutations, which leads to evolution and provide them with increased adaptability (Lin et al., 2019) . To further explore SARS-CoV-2 evolution in human, we have performed phylogenetic analysis based on the aforementioned SARS-CoV-2 in correspondence with their amino acid substitution. Figure 4 . i.....
Document: With the global spread of SARS-CoV-2, its amino acid sequence is also significantly varied (Figure 3) . Usually, RNA viruses have high rate of genetic mutations, which leads to evolution and provide them with increased adaptability (Lin et al., 2019) . To further explore SARS-CoV-2 evolution in human, we have performed phylogenetic analysis based on the aforementioned SARS-CoV-2 in correspondence with their amino acid substitution. Figure 4 . illustrates the phylogenetic tree of SARS-CoV-2 and associated amino acid changes. Our phylogenetic tree demonstrates that BetaCoV/Chongqing/YC01/2020 is the closest SARS-CoV-2 to bat CoV (Bat/Yunnan/RaTG13) as compared to the first reported SARS-CoV-2 (Wuhan-Hu-1_MN908947). Taking BetaCoV/Chongqing/YC01/2020 as a reference group, South Korea SARS-CoV-2 (BetaCoV/South_Korea/SNU01/2020) has 7 amino acid substitutions in six orfs (S, E, orf1a, orf31, and orf8). BetaCoV/Shenzhen/SZTH-001/2020 has total of 16 amino acid substitutions in four coding regions with highest substitution of 11 amino acid residues in orf1a. United States of America (USA) SARS-CoV-2 (BetaCoV/USA/MA1/2020) has 5 amino acid substitutions in N, orf1a, orf1ab, and orf8.
Search related documents:
Co phrase search for related documents- amino acid and BetaCoV SARS: 1
- amino acid and close SARS bat CoV: 1, 2, 3, 4
- amino acid and code region: 1, 2, 3, 4
- amino acid and evolution lead: 1
- amino acid and genetic mutation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- amino acid and genetic mutation high rate: 1
- amino acid and global spread: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- amino acid and high rate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39
- amino acid and high substitution: 1, 2, 3, 4
- amino acid and human SARS evolution: 1, 2, 3, 4, 5, 6
- amino acid and phylogenetic analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78
- amino acid and phylogenetic analysis perform: 1, 2
- amino acid and phylogenetic tree: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76
- amino acid and reference group: 1, 2, 3, 4, 5
- amino acid and RNA virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- amino acid and SARS bat CoV: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76
- amino acid and SARS evolution: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- amino acid and SARS global spread: 1, 2, 3, 4, 5
- amino acid and Wuhan SARS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38
Co phrase search for related documents, hyperlinks ordered by date