Selected article for: "phylogenetic tree and SARS evolution"
Author: Jiao-Mei Huang; Syed Sajid Jan; Xiaobin Wei; Yi Wan; Songying Ouyang
Title: Evidence of the Recombinant Origin and Ongoing Mutations in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
  • Document date: 2020_3_17
    • ID: fw4pmaoc_11
    Snippet: With the global spread of SARS-CoV-2, its amino acid sequence is also significantly varied (Figure 3) . Usually, RNA viruses have high rate of genetic mutations, which leads to evolution and provide them with increased adaptability (Lin et al., 2019) . To further explore SARS-CoV-2 evolution in human, we have performed phylogenetic analysis based on the aforementioned SARS-CoV-2 in correspondence with their amino acid substitution. Figure 4 . i.....
    Document: With the global spread of SARS-CoV-2, its amino acid sequence is also significantly varied (Figure 3) . Usually, RNA viruses have high rate of genetic mutations, which leads to evolution and provide them with increased adaptability (Lin et al., 2019) . To further explore SARS-CoV-2 evolution in human, we have performed phylogenetic analysis based on the aforementioned SARS-CoV-2 in correspondence with their amino acid substitution. Figure 4 . illustrates the phylogenetic tree of SARS-CoV-2 and associated amino acid changes. Our phylogenetic tree demonstrates that BetaCoV/Chongqing/YC01/2020 is the closest SARS-CoV-2 to bat CoV (Bat/Yunnan/RaTG13) as compared to the first reported SARS-CoV-2 (Wuhan-Hu-1_MN908947). Taking BetaCoV/Chongqing/YC01/2020 as a reference group, South Korea SARS-CoV-2 (BetaCoV/South_Korea/SNU01/2020) has 7 amino acid substitutions in six orfs (S, E, orf1a, orf31, and orf8). BetaCoV/Shenzhen/SZTH-001/2020 has total of 16 amino acid substitutions in four coding regions with highest substitution of 11 amino acid residues in orf1a. United States of America (USA) SARS-CoV-2 (BetaCoV/USA/MA1/2020) has 5 amino acid substitutions in N, orf1a, orf1ab, and orf8.

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