Selected article for: "common ancestor and time estimate"
Author: Maciej F Boni; Philippe Lemey; Xiaowei Jiang; Tommy Tsan-Yuk Lam; Blair Perry; Todd Castoe; Andrew Rambaut; David L Robertson
Title: Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic
  • Document date: 2020_3_31
    • ID: h2uc7ria_7
    Snippet: To gauge the length of time this lineage has circulated in bats we estimate the time to most recent common ancestor (tMRCA) of SARS-CoV-2 and RaTG13. We use three bioinformatic approaches to remove the effects of recombination, and we combine these approaches to identify putative non-recombinant regions that can be used for reliable phylogenetic reconstruction and dating. Collectively our analyses point to bats being the primary reservoir for the.....
    Document: To gauge the length of time this lineage has circulated in bats we estimate the time to most recent common ancestor (tMRCA) of SARS-CoV-2 and RaTG13. We use three bioinformatic approaches to remove the effects of recombination, and we combine these approaches to identify putative non-recombinant regions that can be used for reliable phylogenetic reconstruction and dating. Collectively our analyses point to bats being the primary reservoir for the SARS-CoV-2 lineage. While it is possible that pangolins may have acted as an intermediate species facilitating transmission to humans, the evidence is consistent with the virus having evolved in bats resulting in bat sarbecoviruses that can replicate in the upper respiratory tract of both humans and pangolins (Zhang and Holmes, 2020; Zhou et al., 2020a) .

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