Author: Monika Abedin Sigg; Tabea Menchen; Jeffery Johnson; Chanjae Lee; Semil P. Choksi; Galo Garcia; Henriette Busengdal; Gerard Dougherty; Petra Pennekamp; Claudius Werner; Fabian Rentzsch; Nevan Krogan; John B. Wallingford; Heymut Omran; Jeremy F. Reiter
Title: Evolutionary proteomics uncovers ciliary signaling components Document date: 2017_6_22
ID: 9y8r277c_27
Snippet: To assess whether some of the identified GPCR signaling proteins can localize to 337 mammalian cilia, we expressed a GFP-tagged version of a sea urchin homolog of Opioid 338 receptor µ1 (OPRM1) that we named OPRM1L in RPE-1 cells and found that it localized to cilia 339 ( Figure S3A ). The GPCR signal transduction component b-Arrestin-1/2 can localize to one end 340 of cilia (Pal et al., 2016) . As b-Arrestin-1 (ARRB1) was detected in the sea ur.....
Document: To assess whether some of the identified GPCR signaling proteins can localize to 337 mammalian cilia, we expressed a GFP-tagged version of a sea urchin homolog of Opioid 338 receptor µ1 (OPRM1) that we named OPRM1L in RPE-1 cells and found that it localized to cilia 339 ( Figure S3A ). The GPCR signal transduction component b-Arrestin-1/2 can localize to one end 340 of cilia (Pal et al., 2016) . As b-Arrestin-1 (ARRB1) was detected in the sea urchin ciliome, we 341 also examined the localization of sea urchin ARRB1-GFP in RPE-1 cells and found that, like the 342 mammalian ortholog, it was enriched at one ciliary end ( Figure S3B ). 343
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